A controversial hypothesis in RNA biology is that extracellular microRNAs (miRNAs), including those in biofluids, have non‐cell‐autonomous activities. Several studies have characterized biofluid miRNA profiles in healthy or diseased individuals but generally have failed to identify distinct disease signatures. It remains unclear whether alterations in fluid miRNA levels are simply indicators of physiological change or whether miRNAs are taken up by new cells at concentrations sufficient to affect gene expression. There are limitations to biofluid miRNA studies performed to date: methodology (...) for isolating and quantifying biofluid miRNAs is not standardized across studies; mechanistic details of miRNA release and uptake are incomplete; and efforts to assess non‐cell‐autonomous effects of extracellular miRNAs have employed predominantly in vitro strategies. We describe controversies and questions that need to be addressed to test possible in vivo roles of extracellular miRNAs and propose model organisms with rich genetic toolkits for carrying out in vivo functional analyses. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Alexander and Persian WomenElizabeth Donnelly CarneyPerhaps the most dominant symbol of conquest in Greek literature is that of the captive woman, the wife, the mother, the daughter of some once great warrior now slave and perhaps concubine to the man who killed him. It is the image of Andromache led away to do demeaning work for some Greek that most haunts Hector when he foresees defeat; he hopes he (...) is dead before it happens (Il. 6.450–65). As the quarrel over Chryseis and Briseis demonstrates (Il. 1.26–31, 110–85), possession of the women of your enemy both symbolizes victory and is victory. 1 The family of Alexander’s mother, the Aeacids, asserted their essential Hellenism via connection to the great saga of Troy, not only by claiming descent from Achilles, through his son Neoptolemus, but also from Andromache, the captive of Neoptolemus. 2The strong influence of the story of Troy in Greek literature has created the image of a male Greek conquering and taking captive an Asian woman. 3 By the fifth century Greeks had defined themselves as superior because they had defeated Asians, Trojans and Persians had been conflated, and by then both were characterized as mere barbarians. 4 Thus the capture of Asian women by Greeks could be understood as part of the victory of civilization over barbarism.It is not incidental that the image is primarily one of a captive woman rather than a captive child; from the point of view of the ancient [End Page 563] world, the woman is the more compelling figure. 5 More important, women, perhaps because they themselves could not generate status easily, were perceived to have axi ma (‘reputation’), 6 to carry the status of their fathers and/or husbands or sons with them, status which could then be transmitted to the male who possessed them—thus the importance of Andromache, widow of the greatest Trojan warrior.Sexual possession of these bearers of status, whether legitimated by marriage or not, was a particularly powerful symbol of victory—a kind of second victory, both sexual and military, over the males to whom the women had belonged. Victory as rape and conquest as sexual union were commonplaces of Greek literature, metaphors but more than metaphors. 7Thus, that Alexander came into control of the women of the Persian royal family and other women of the Persian elite after the battle of Issus in 333 meant both that he had achieved a real victory and that he had acquired a potent set of symbols of that victory which he could manipulate to his own ends in the varying contexts of Macedonian, Greek, and Persian audiences. However, these Persian women were or could be, thanks to another old Greek literary tradition, dangerously ambiguous symbols to the Greeks and Macedonians. This tradition insisted that Persian monarchy had lost its original toughness by the fourth century and had become overly steeped in luxury. Much of this decadence was understood as effeminacy, often blamed on the role of royal women, especially in the education of princes (e.g., Plato Laws 3.694a–696a). If anything, [End Page 564] Greek tradition exaggerated the power and influence of royal Persian women, particularly the mothers of kings. Stories of scheming and seductive queens playing succession politics abounded. 8As is now generally recognized, most of this tradition is false, 9 a product of the Hellenic inclination to conceptualize in terms of polarities and to associate two different sorts of “others,” the foreigner and the female, 10 coupled with Hellenic suspicion of the role of women in monarchy, 11 and envy of the comparatively rich Persian culture. Greeks claimed to pride themselves on their austerity and to disdain the material wealth of the Persians, but in practice proved vulnerable to it. 12 In fact, a considerable part of the appeal and motivation for warfare in general and the Graeco-Macedonian conquest of the Persian Empire in particular was the acquisition of that wealth and luxury supposedly so disdained and so often associated with women. 13Whatever one believes about the ethnicity of ancient Macedonians, one cannot assume that Macedonian views were identical to those [End Page... (shrink)

OBJECTIVE: This paper addresses the question of the circumstances which lead clinicians to use legal coercion in the management of patients with severe anorexia nervosa, and explores similarities and differences between such formal coercion and other forms of 'strong persuasion' in patient management. METHOD: Logistic regression and other statistical analysis was undertaken on 75 first admissions for anorexia nervosa from a sample of 117 successive admissions to an eating disorder facility in New South Wales, Australia, where an eating disorder was (...) the primary diagnosis. Admissions with other primary diagnoses, such as bulimia nervosa (25 episodes), and entries with a co morbid diagnosis (e.g. depression or opiate overdose), were discarded, leaving 96 admissions by 75 individuals. RESULTS: Resort to measures of legal coercion into treatment was found to be associated with three main indicators: the patient's past history (number of previous admissions); the complexity of their condition (the number of other psychiatric co morbidities); and their current health risk (measured either by Body Mass Index or the risk of re-feeding syndrome). CONCLUSIONS: Our study is consistent with the few earlier studies about indicators for legal coercion in anorexia nervosa management, and suggests that clinicians use legal coercion very sparingly, distinguishing legal coercion from other forms of close clinical management of patients. (shrink)

It is estimated that one in ten U.S. adults suffers from chronic insomnia. If left untreated, chronic insomnia reduces quality of life and increases risk for psychiatric and medical disease, especially depression and anxiety. There are two forms of insomnia: secondary insomnia, in which it is comorbid with another condition such as psychiatric disorders, chronic pain conditions, or cardiopulmonary disorders, and primary insomnia, which does not coexist with any other disorder. This treatment program uses cognitive-behavioral therapy methods to correct poor (...) sleep habits. CBT has been proven in multiple studies to improve sleep hygiene by reducing time spent in bed before sleep onset, reducing time spent awake after first sleep onset, and increasing the quality and efficiency of sleep. Developed by the authors, this evidence based treatment can be used for both primary and secondary insomnia sufferers. Patients are first given information about healthy sleep and the reasons for improving sleep habits, then a behavioral program is developed to address that patient's specific sleep problems. Use of sleep logs, assessment forms, and other homework allows client and therapist to work together to develop an effective sleep regimen tailored specifically for each client. Finally, several sessions are dedicated to increasing compliance and problem-solving.TreatmentsThatWork represents the gold standard of behavioral healthcare interventions!BL All programs have been rigorously tested in clinical trials and are backed by years of researchBL A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to dateBL Our books are reliable and effective and make it easy for you to provide your clients with the best care availableBL Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivatedBL A companion website offers downloadable clinical tools and helpful resourcesBL Continuing Education Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (shrink)

Justifying involuntary psychiatric treatment on the basis of a judgment that a person lacks capacity is usually expressed in terms of a person’s ability to make a decision about his or her health and treatment. Typically, this relates to the ability to refuse treatment. Exactly what “capacity” means, however, and how one determines when another individual lacks capacity, or lacks sufficient capacity, in this context is particularly controversial, with the United Nations Committee on the Rights of Persons with Disabilities insisting (...) that involuntary treatment be abandoned altogether and capacity tests avoided.Capacity is a concept that has multiple meanings and applications across different disciplines and... (shrink)

The Red Market: On the Trail of the World’s Organ Brokers, Bone Thieves, Blood Farmers, and Child Traffickers Content Type Journal Article Category Book Review Pages 1-3 DOI 10.1007/s11673-012-9361-3 Authors Dominique E. Martin, 39 Eltham Street, Flemington, 3031 Australia Journal Journal of Bioethical Inquiry Online ISSN 1872-4353 Print ISSN 1176-7529.

In “Prozac or Prosaic Diaries?”, Ginger Hoffman and Jennifer Hansen examine gendered messages in popular depression memoirs, using narrative self-constitution theory to emphasize the damaging effects such messages can have on women readers. In doing so, they bring a welcome feminist perspective to matters of mental health, as well as raising thought-provoking questions about depression memoirs, a genre that can have a far-reaching impact on public opinions about mental illness. Overall, Hoffman and Hansen do an excellent job of explaining (...) the philosophical concepts that form a basis for their arguments. This work allows even relative newcomers to philosophy to follow along, co-inspecting the... (shrink)

For twenty years, the renowned philosopher of science Sandra Harding has argued that science and technology studies, postcolonial studies, and feminist critique must inform one another. In The Postcolonial Science and Technology Studies Reader, Harding puts those fields in critical conversation, assembling the anthology that she has long wanted for classroom use. In classic and recent essays, international scholars from a range of disciplines think through a broad array of science and technology philosophies and practices. The contributors reevaluate conventional accounts (...) of the West’s scientific and technological projects in the past and present, rethink the strengths and limitations of non-Western societies’ knowledge traditions, and assess the legacies of colonialism and imperialism. The collection concludes with forward-looking essays, which explore strategies for cultivating new visions of a multicultural, democratic world of sciences and for turning those visions into realities. Feminist science and technology concerns run throughout the reader and are the focus of several essays. Harding provides helpful background for each essay in her introductions to the reader’s four sections. Contributors Helen Appleton Karen Bäckstrand Lucille H. Brockway Stephen B. Brush Judith Carney Committee on Women, Population, and the Environment Arturo Escobar Maria E. Fernandez Ward H. Goodenough Susantha Goonatilake Sandra Harding Steven J. Harris Betsy Hartmann Cori Hayden Catherine L. M. Hill John M. Hobson Peter Mühlhäusler Catherine A. Odora Hoppers Consuelo Quiroz Jenny Reardon Ella Reitsma Ziauddin Sardar Daniel Sarewitz Londa Schiebinger Catherine V. Scott Colin Scott Mary Terrall D. Michael Warren. (shrink)

Epistemic Permissivists face a special problem about the relationship between our first- and higher-order attitudes. They claim that rationality often permits a range of doxastic responses to the evidence. Given plausible assumptions about the relationship between your first- and higher-order attitudes, it can't be rational to adopt a credence on the edge of that range. But Permissivism says that, for some such range, any credence in that range is rational. Permissivism, in its traditional form, cannot be right. I consider some (...) new ways of developing Permissivism to avoid this argument, but each has problems of its own. (shrink)

Stalnaker's Thesis about indicative conditionals is, roughly, that the probability one ought to assign to an indicative conditional equals the probability that one ought to assign to its consequent conditional on its antecedent. The thesis seems right. If you draw a card from a standard 52-card deck, how confident are you that the card is a diamond if it's a red card? To answer this, you calculate the proportion of red cards that are diamonds -- that is, you calculate the (...) probability of drawing a diamond conditional on drawing a red card. Skyrms' Thesis about counterfactual conditionals is, roughly, that the probability that one ought to assign to a counterfactual equals one's rational expectation of the chance, at a relevant past time, of its consequent conditional on its antecedent. This thesis also seems right. If you decide not to enter a 100-ticket lottery, how confident are you that you would have won had you bought a ticket? To answer this, you calculate the prior chance--that is, the chance just before your decision not to buy a ticket---of winning conditional on entering the lottery. The central project of this article is to develop a new uniform theory of conditionals that allows us to derive a version of Skyrms' Thesis from a version of Stalnaker's Thesis, together with a chance-deference norm relating rational credence to beliefs about objective chance. (shrink)

The epistemic thesis is the thesis that a 'might' counterfactual like 'If Matt had gone to the parade, David might have gone to the parade' has the same meaning as 'Maybe, if Matt had gone to the parade, David would have gone to the parade.' I offer a new theory of the counterfactual interpretation of the modal 'might' on which 'might' has the same meaning as 'maybe would'. And I show that, when coupled with a plausible semantics for 'if' clauses, (...) my theory validates the epistemic thesis. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Ethics in Light of ChildhoodDavid Cloutier (bio)Review of Ethics in Light of Childhood John Wall Washington, D.C.: Georgetown University Press, 2010. 204 pp. $34.95.John Wall’s ambitious volume contends that “considerations of childhood should not only have greater importance but fundamentally transform how morality is understood” (1). He rightly suggests that “the story of childhood cannot be told in one-dimensional formulas of either innocence and vulnerability or unruliness and (...) undevelopment” (7), but instead require a new paradigm for ethics: “childism.” He questions three historical views of childhood: the “top-down,” the “bottom-up,” and the developmentalist. Wall splendidly moves beyond these views and demonstrates that considering children should instruct us in the limitations of ordinary approaches to ethics—not only for children’s sake but for adults too.How so? Wall’s constructive section considers ontology, teleology, and de-ontology. In them, relying heavily on twentieth-century continental philosophy, supplemented by some social-scientific literature and numerous anecdotal examples, he develops an overall approach to the moral life. First, he argues for an ontology of “restless and endless play” (36) reflective of the human capacity for creativity possessed by both children and adults. Secondly, the moral life has a teleology of “narrative expansion,” with a constant movement toward a “more richly diverse life story” (60). Finally, moral obligation involves a constant “decentering” of the self in which “the world I create for myself should be disrupted and stretched out as far as possible by genuine human difference” (88). Building on the insights of top-down and bottom-up traditions, and going beyond the “flatly unilinear assumptions” of developmental “stageism” (81) ethics involves a constant circularity, exemplified in the final three chapters on specific issues. For example, families who “create increasingly expansive family worlds” engage in top-down transmission of tradition, developmental formation of relationality, and bottom-up nurturing of otherness (149). These qualities apply not only to children but to parents as well, and thus satisfy Wall’s desire for an ethics that is fully “child-inclusive” and that does not privilege adult agents. He succeeds admirably at demonstrating that the real agency children actually possess and exercise, as well as their vulnerability and passivity, are not simply incomplete versions of what adults possess fully.I would raise two concerns. First, the book works so hard to avoid any kind of linearity that criteria enabling judgment seem lacking—for example, surely some [End Page 195] forms of “disruption” are not to be welcomed (especially by children). The telos of “narrative expansion” so strongly refuses to privilege any perspective that it threatens to empty out what one might gingerly call “adult commitments”—to stable love, production, civic life, and fine arts—all of which require virtue (absent here), and which seem necessary for children to flourish. Aspiring “to go on creating oneself endlessly” (58) can be a fruitful depiction of adult life, or it can be an immature escapism. Without a thicker telos, the distinction is difficult to make.Second, his category of “childism” (3) forces him to artificially avoid any telos of maturation. In parallel with other “isms” (e.g., feminism), he argues that children are “full human beings,” live in “fully meaningful moral worlds,” and are “full participants in... human moral experience” (29). “Full” appears throughout, but the inclusion parallel clashes with maturation in human life. True, children and adults have both agency and vulnerability (39), but children, generally speaking, are more vulnerable and are less capable agents, and thus will have particular needs (and also offer particular gifts to adults). “Childism” sometimes obscures the particularities of childhood, and how we are bodily and culturally directed toward some “maturity.” Yet these concerns should not diminish Wall’s achievement in displaying how childhood can teach adults much about ethics.David CloutierMount St. Mary’s UniversityDavid Cloutier David Cloutier is an associate professor of theology at Mount St. Mary’s University. He received his BA from Carleton College and his PhD from Duke University. He is the author of Love, Reason, and God’s Story: An Introduction to Catholic Sexual Ethics (Anselm/St. Mary’s Press, 2008) and editor of Leaving... (shrink)

According to quality theories of love, love is fitting by virtue of properties of the loved person. Despite their immediate plausibility, quality theories have met with many objections. Here I focus on two that strike at the heart of what makes the quality theory an appealing account of love, specifically, the theory’s ability to accommodate the fact that loving someone is a way of valuing them for who they are. The fungibility objection and the problem of love’s object maintain that (...) if a person is loved on the basis of their qualities, they are not valued in the right kind of way. I propose a new kind of quality theory which both answers these objections and is independently well-motivated. Specifically, I argue that to love a person as a whole, one must value them as an organic unity. (shrink)

The thesis that mental states extend beyond the skull, otherwise known as the extended mind thesis, has attracted considerable philosophical attention and support. It has also been accused of lacking practical import. At the same time, the field of psychiatry has remained largely unacquainted with ExM, tending to rely instead upon what ExM proponents would consider to be outdated models of the mind. ExM and psychiatry, therefore, have much to offer one another, but the connection between the two has remained (...) largely unexplored. Here, I consider what implications ExM may have for psychiatry and, in so doing, reveal how psychiatry may lend practical import to ExM. First, I detail the possibility of the extension of one mental state relevant to psychiatry. I augment this example by surveying other possibilities for extension in the context of psychiatric diagnoses. I then consider ways in which such extensions might alter psychiatric diagnosis and treatment. Overall, I argue that recognition of the truth of ExM could alter the diagnostic status of certain individuals by correcting both false positives and false negatives, re-conceptualize certain aspects of treatment, help us re-envision psychiatric research, and potentially increase empathy towards those individuals considered to be mentally disordered or mentally different. (shrink)

Anscombe famously said that there are some act types that can only be done intentionally. We defend this claim: some act types are essentially intentional. We argue that Ving intentionally is itself essentially intentional: it is not possible to be non-intentionally Ving intentionally. And we show how this explains why various other act types—such as trying, lying, and thanking—are essentially intentional. Finally, building on Piñeros Glassock (2020) and Beddor & Pavese (2022), we explain how this makes trouble for the thesis (...) that if I am Ving intentionally, I know that I am Ving. (shrink)

This paper is about progressive aspect. We defend a new principle that we call ‘Progressive Specificity’: if you are Ving and to V is to X or to Y, then you are Xing or you are Ying. We offer six arguments for Progressive Specificity. We then suggest that those six arguments extend to the futurative progressive. We conclude by comparing Progressive Specificity to Conditional Excluded Middle. -/- .

Accuracy-first epistemology says that the rational update rule is the rule that maximizes expected accuracy. Externalism says, roughly, that we do not always know what our total evidence is. It’s been argued in recent years that the externalist faces a dilemma: Either deny that Bayesian Conditionalization is the rational update rule, thereby rejecting traditional Bayesian epistemology, or else deny that the rational update rule is the rule that maximizes expected accuracy, thereby rejecting the accuracy-first program. Call this the Bayesian Dilemma. (...) Here is roughly how the argument goes. Schoenfield (2017) has shown that following Metaconditionalization maximizes expected accuracy. But if externalism is true, Metaconditionalization is not Bayesian Conditionalization. Therefore, the externalist must choose between the rule that maximizes expected accuracy (Metaconditionalization) and Bayesian Conditionalization. I am not convinced by this argument; once we make the premises fully explicit, we see that it relies on assumptions that the externalist has every reason to reject. Still, I think that the Bayesian Dilemma is a genuine dilemma. I give a new argument—I call it the continuity argument—that doesn’t make any assumptions the externalist rejects. Roughly, I show that if you're sufficiently confident that you will correctly identify your evidence, then you'll expect adopting a rule that I call Accurate Metaconditionalization to be more accurate than adopting Bayesian Conditionalization. (shrink)

This paper is about four inferences patterns governing conditionals: Transitivity, Simplification, Contraposition, and Antecedent Strengthening. Transitivity, Simplification, and Contraposition are intuitively compelling. Although Antecedent Strengthening may seem less attractive at first, close attention to the full range of data reveals that it too has considerable appeal. An adequate theory of conditionals should account for these facts. The strict theory does so by validating them. But the variably strict theory invalidates them. So the variably strict theorist faces a question: why do (...) we find these inferences so compelling? In this paper, I suggest an answer on her behalf: that they are reasonable inferences in the sense introduced by Stalnaker (1975). -/- . (shrink)

In this paper, I offer one moral reason to eschew antidepressant medication in favor of cognitive therapy, all other things being equal: taking antidepressants can be a form of self-objectification. This means that, by taking antidepressants, one treats oneself, in some sense and some cases, like a mere object. I contend that, morally, this amounts to a specific form of devaluing oneself. I argue this as follows. First, I offer a detailed definition of “objectification” and argue for the possibility of (...) self-objectification on this definition. I then explain why this form of self-objectification is morally problematic. (Morally problematic does not mean morally impermissible. It means, instead, that there is a moral reason opposing the activity in question). After, I describe how taking antidepressants can count as self-objectifying. Finally, I defend my thesis against a key objection offered by Levy. Thus, assuming that antidepressants and cognitive therapy are equally efficacious, and that all other things are equal, the self-objectifying character of antidepressants is a compelling reason to regard cognitive therapy as a first-choice treatment for depression. (shrink)

Abstract This paper explores Reiner Schürmann’s account of perigrinal ontology from the perspective of Meister Eckhart. What is so extraordinary about his work is its retrieval of nuances in Plato’s philosophy of mind. Professor Schürmann’s approach to Philosophy focused on a philosopher’s philosophy of mind. For example, his course titles, such as Augustine’s Philosophy, were listed and taught in Augustine’s Philosophy of Mind. The advantage of his approach can best be seen in his study of the Medieval Philosopher Meister Eckhart. (...) In this work, Professor Schürmann totalizes the relationship between the will and the intellect and unites the different categories of Platonic philosophy under the concept of perigrinal ontology. Instead of treating epistemology or aesthetics in isolation, they are examined as they relate to ontology. In Plato’s epistemology, the highest form of knowing is different; at its highest point, knowledge is a seeing. Meister Eckhart and the other Neoplatonic philosophers continued the argument that Plato initiated. This is not an instance of Gnosticism in that the successors of Plato in the Christian tradition are not introducing new material but are extending Plato’s philosophy. At the center of the controversies about Meister Eckhart’s alleged departure from Christian doctrine is the oneness with God. Here, Professor Schürmann acts like a good editor. He painstakingly draws out pertinent distinctions to demonstrate Meister Eckhart’s adherence to tradition. It is interesting in this light to consider what Saint Thomas Aquinas has said on some of these same issues. One can see, too, that Meister Eckhart is a good deal closer to Saint Thomas than is generally thought. Saint Thomas's writings are full of references to Neoplatonic philosophers, but he also actively engages with their ideas. Though exploring this is beyond this paper's scope, Saint Thomas’s commentary of the Christian Neoplatonist Pseudo Dionysius primarily supports this point. We also need to recall that the period in which all this unfolded was a period in history marked by the democratization of religion. More importantly, Meister Eckhart’s time was informed by the democratization of theology. Meister Eckhart’s writings and personal commitment to that project are noteworthy in this context. His decision to teach women in religious orders advanced theology, a historical breakthrough. There are some notable debates that Professor Schürmann addressed in this work. Perhaps chief among these is the overly close connection between the writings of Meister Eckhart and that of the late Heidegger. It had been suggested that Martin Heidegger’s interest in Zen Buddhism was thought to include that of Meister Eckhart. Waiting upon Being and detachment or releasement were similar in these three schools of thought. Professor Schürmann viewed this as a form of syncretism, the mashing up of ideas that seem similar but have important distinctions. For Professor Schürmann, the absolute absence of the faculty of the will in Meister Eckhart’s work distinguished him from these other philosophies. It is striking that Professor Schürmann repeatedly cites texts where Meister Eckhart sees the highest form of knowledge as purely a feature of the intellect. He even goes so far as to note that the will is almost absent from Meister Eckhart’s philosophy of mind. -/- . (shrink)

In the 2000s, several psychiatrists cited the lack of relational disorders in the DSM-IV as one of the two most glaring gaps in psychiatric nosology, and campaigned for their inclusion in the DSM-5. This campaign failed, however, presumably in part due to serious “ontological concerns” haunting such disorders. Here, I offer a path to quell such ontological concerns, adding to previous conceptual work by Jerome Wakefield and Christian Perring. Specifically, I adduce reasons to think that collective disorders are compatible with (...) key metaphysical commitments of contemporary scientific psychiatry, and argue that if one accepts the existence of mental disorders in individuals as medical, then one has good reasons to accept the existence of collective disorders as medical. First, I outline how collective disorders are reconcilable with both the harmful dysfunction model of disorder and a denial of mind-body dualism. I then identify some potential weaknesses in the main pre-existing example of a collective disorder, offering my own examples as supplements. These examples’ medical plausibility is bolstered by: work in philosophy of biology on the generalized selected effects theory of function, and work in analytic philosophy of mind on collective mentality. Finally, after offering preliminary responses to the objection that the recognition of collective disorders may lead to an overpathologization of everyday life, I spell out ways in which this recognition may have empowering effects for some would-be patients; for example, by providing substance to the notion of a “sane response to an insane world.”. (shrink)

In this opening essay, Ginger Danto remembers her father's early life and time travelling in France and Italy, as well as his art‐making—in particular his woodcuts.

The stories we tell of psychiatric disability1 and gender play a crucial role not only in the experience of psychiatric disorders, but in who disordered individuals are in the most literal sense. Recent theories of the self—so-called narrative self-constitution views, or “narrative theories”—contend that the self is, fundamentally, constituted by a narrative one tells about oneself. Furthermore, this narrative almost certainly absorbs elements from surrounding cultural scripts. Thus, narrative self-constitution views can shed light on some of the ways in which (...) cultural... (shrink)

This paper emphasizes a need to recognize sexual refusals both in public discourse and in the context of particular interactions. I draw on sociolinguistic work on the structure of refusals to illuminate a much-discussed case of alleged sexual violence as well as to inform how we ought to think and talk about sexual consent and refusal more generally. I argue on empirical and ideological grounds that we ought to impute the same significance to refusals uttered in sexual contexts as we (...) do to those uttered in nonsexual contexts. Finally, I propose an amendment to the definition of affirmative consent that would put it in line with the conclusions drawn in the rest of the paper. (shrink)

In A Logic in Madness, Aaron J. Hauptman presents the case of Mr. A, a college-age man suffering from the unexpected and cruel severance of a romantic relationship. This breakup caused Mr. A to become severely depressed, harboring a desire to starve himself. However, Mr. A adamantly refused any sort of pharmacotherapy for his condition. Being someone who has “a doggedness with rationality” and who cares deeply about being logical, he offered several arguments and reasons for his refusal. One of (...) these was: “I am depressed for a very good reason and if, because of that, I have these feelings then it is right for me to have these feelings”. He further regarded drug therapy as “dishonest,”... (shrink)

The epistemic thesis is the thesis that a ‘might’ counterfactual like (1) has the same meaning as (2). (1) If Matt had gone to the parade, David might have gone to the parade. (2) Maybe, if Matt had gone to the parade, David would have gone to the parade. In this paper, I give a compositional semantics for ‘might’ counterfactuals that predicts the epistemic thesis. I offer a new theory of the counterfactual interpretation of the modal ‘might’ — the interpretation (...) it receives in (1) — and I show that, when coupled with a plausible semantics for ‘if’ clauses, my theory validates the epistemic thesis. (shrink)

Eoin Carney | : Continuing on from recent discussions on the overlap between Paul Ricoeur’s philosophy and care ethics, this article will aim to clarify the status of practice in Ricoeur’s work. I will argue that even though Ricoeur’s philosophy is indeed marked by its “desire for a foundation,” as care ethicist Joan Tronto has pointed out, this aim is more of a fragile wager than a principle, and is always at risk of being overturned by practices and other (...) worldviews. I will demonstrate this point by arguing that Ricoeur’s hermeneutic approach to practice leads to the view that objective methods of knowledge and explanation are always grounded by the broader hermeneutic task of practical understanding and care for the self; in moral reasoning, Ricoeur’s analysis of the conflict between respect for the rule and respect for persons results in his prioritizing of respect for the singular other rather than the universal rule, meaning that the other can always disrupt and reorient universal or foundational modes of reasoning; and finally within healthcare relations Ricoeur aims to develop an alternative understanding of respect that places it in a dialectical relation with care. These practice-oriented readings of hermeneutics, morality, and respect aim to open up a dialogue between care ethics and philosophical approaches that have often been placed outside of care ethics. | : Poursuivant les récentes discussions concernant les recoupements entre la philosophie de Paul Ricoeur et les éthiques du care, cet article a pour objectif de clarifier le statut de la pratique dans l’oeuvre de Ricoeur. Je soutiendrai que même si la philosophie ricoeurienne est bien marquée par un « désir d’un fondement », ainsi que l’éthicienne du care Joan C. Tronto le souligne, cet objectif repose plus sur un pari que sur un véritable principe, et risque toujours d’être renversé par les pratiques ou d’autres visions du monde. Je démontrerai cela en soutenant trois arguments. 1) L’approche herméneutique de Ricoeur concernant la pratique mène à penser que les méthodes objectives de connaissance et d’explication sont toujours soutenues par une tâche herméneutique plus large de la compréhension pratique et du souci de soi. 2) En ce qui a trait au raisonnement moral, l’analyse de Ricoeur sur le conflit entre le respect de la règle et le respect de la personne accorde la priorité au respect de l’autre singulier plutôt que de la règle universelle. Ainsi, l’autre peut toujours perturber et réorienter l’universel ou les modes fondateurs du raisonnement. 3) Réfléchissant aux relations thérapeutiques, Ricoeur tend à suggérer une nouvelle compréhension du respect qui se place dans une relation dialectique avec le souci. Ces lectures – de l’herméneutique, de la moralité et du respect – orientées vers la pratique ouvrent la voie à un dialogue entre les éthiques du care et des approches philosophiques que l’on considère souvent éloignées de celles-ci. (shrink)

As neuroscience has gained an increased ability to enchant the general public, it has become more and more common to appeal to it as an authority on a wide variety of questions about how humans do and should act. This is especially apparent with the question of gender roles. The term ‘neurosexism’ has been coined to describe the phenomenon of using neuroscientific practices and results to promote sexist conclusions; its feminist response is called ‘neurofeminism’. Here, our aim is to survey (...) the phenomena of neurosexism and neurofeminism using a largely philosophical approach, incorporating concepts from the philosophy of mind, the philosophy of science, ethics, and feminist philosophy. First, we delineate how neuroscientific studies purporting to show sex brain differences may be prone to bias at a number of methodological levels – including the choice of categories to be studied, and the choice of tools for data gathering, analysis, and presentation. Then, we show how interpretations of such studies may wrongly assume the notion of ‘hard-wiring’. Furthermore, lack of attention to distinctions within philosophy of mind may result in a mistaken supposition that brain differences lead to mental and/or psychological and/or behavioral ones. It is not difficult to see how these forms of neurosexism, leading to claims of ‘hard-wired’ gender differences that map onto traditional and harmful gender stereotypes, raise ethical questions. We conclude by briefly considering one: are the harms caused by neurosexist studies and their interpretations outweighed by their potential benefits? (shrink)

We argue that the counterfactual representations of popular culture, like their religious cognates, are shaped by cognitive constraints that become visible when considered in aggregate. In particular, we argue that comic-book literature embodies core intuitions about sociality and its maintenance that are activated by the cognitive problem of living in large groups. This leads to four predictions: comic-book enforcers should be punitively prosocial, be quasi-omniscient, exhibit kin-signalling proxies and be minimally counterintuitive. We gauge these predictions against a large sample of (...) 19,877 characters that were derived from 72,611 comics using data scraping techniques. Our results corroborate the view that cognitive constraints exercise a selective effect on the transmission of popular culture. (shrink)

Prozac has been lauded by Peter Kramer for instilling potentially “liberating” personality traits in women such as assertiveness, resilience, and confidence. Witnessing these effects, Kramer declares that there is a sense in which antidepressants like Prozac are “feminist.” In this paper, we scrutinize Kramer’s claim from myriad angles. We evaluate putatively “feminist” uses of antidepressants in both women who are diagnosed with clinical depression and women thought to use them instead for “enhancement” purposes. We conclude that there are, indeed, some (...) ways in which Prozac is feminist, and some ways in which it is decidedly antifeminist. (shrink)